Chronopharmacology: New Insights and Therapeutic Implications

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Chronopharmacology: new insights and therapeutic implications.

Most facets of mammalian physiology and behavior vary according to time of day, thanks to endogenous circadian clocks. Therefore, it is not surprising that many aspects of pharmacology and toxicology also oscillate according to the same 24-h clocks. Daily oscillations in abundance of proteins necessary for either drug absorption or metabolism result in circadian pharmacokinetics, and oscillatio...

متن کامل

Multiple Myeloma: New Insights and Therapeutic Approaches.

This review discusses the evolution of novel diagnostic and treatment strategies for multiple myeloma based upon increased understanding of basic disease pathogenesis. Although myeloma has remained an incurable illness to date, these new developments will derive treatments to improve outcome and achieve eventual cure. In Section I, Dr. Kyle reviews the results of current therapy for multiple my...

متن کامل

Insights into the autistic disorder and potential therapeutic approaches

Autism and autism spectrum disorders (ASDs) such as Rett syndrome and Asperger syndromeare enigmatic and complex neurodevelopmental disorders, thought to have originated inparticular interactions of genetic and environmental factors. Despite the extensive research,exact mechanism of pathogenesis is not still completely understood. ASDs are characterizedby deficits and abnormalities in communica...

متن کامل

Recent Advances in Basic Science Psychological Stress in Ibd: New Insights into Pathogenic and Therapeutic Implications

Correspondence to: Professor D S Rampton, Endoscopy Unit, Royal London Hospital, London E1 1BB, UK; [email protected] _________________________ SUMMARY Psychological stress has long been reported anecdotally to increase disease activity in inflammatory bowel disease (IBD), and recent well designed studies have confirmed that adverse life events, chronic stress, and depression increase the li...

متن کامل

Unfolding the Role of Large Heat Shock Proteins: New Insights and Therapeutic Implications

Heat shock proteins (HSPs) of eukaryotes are evolutionarily conserved molecules present in all the major intracellular organelles. They mainly function as molecular chaperones and participate in maintenance of protein homeostasis in physiological state and under stressful conditions. Despite their relative abundance, the large HSPs, i.e., Hsp110 and glucose-regulated protein 170 (Grp170), have ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Annual Review of Pharmacology and Toxicology

سال: 2014

ISSN: 0362-1642,1545-4304

DOI: 10.1146/annurev-pharmtox-011613-135923